ASCENT

SUBCELLULAR LOCATION: Isoform 3: Secreted {ECO:0000269|PubMed:15496415}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

COX5A_HUMAN
P20674 - Cytochrome c oxidase subunit 5A, mitochondrial

FUNCTION: This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

SUBCELLULAR LOCATION: Mitochondrion inner membrane.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

NUCB1_HUMAN
Q02818 - Nucleobindin-1

FUNCTION: Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity). {ECO:0000250}.

SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q63083}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63083}; Lumenal side {ECO:0000250|UniProtKB:Q63083}. Cytoplasm {ECO:0000250|UniProtKB:Q63083}. Secreted {ECO:0000250|UniProtKB:Q63083}. Note=A small fraction of the protein may be cytoplasmic. {ECO:0000250|UniProtKB:Q63083}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

TM205_HUMAN
Q6UW68 - Transmembrane protein 205

FUNCTION: In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin. {ECO:0000269|PubMed:20589834}.

SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:20589834}; Multi-pass membrane protein {ECO:0000269|PubMed:20589834}. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

LAMB1_HUMAN
P07942 - Laminin subunit beta-1

FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}.

SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

TGON2_HUMAN
O43493 - Trans-Golgi network integral membrane protein 2

FUNCTION: May be involved in regulating membrane traffic to and from trans-Golgi network.

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single- pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

TNR16_HUMAN
P08138 - Tumor necrosis factor receptor superfamily member 16

FUNCTION: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. {ECO:0000250, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138}.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

C99L2_HUMAN
Q8TCZ2 - CD99 antigen-like protein 2

FUNCTION: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). {ECO:0000250}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000250}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

GPI8_HUMAN
Q92643 - GPI-anchor transamidase

FUNCTION: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Single-pass type I membrane protein {ECO:0000269|PubMed:11483512}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

ITA7_HUMAN
Q13683 - Integrin alpha-7

FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

DJC10_HUMAN
Q8IXB1 - DnaJ homolog subfamily C member 10

FUNCTION: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. {ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:18400946, ECO:0000269|PubMed:19122239, ECO:0000269|PubMed:23769672}.

SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:23769672}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

LRP8_HUMAN
Q14114 - Low-density lipoprotein receptor-related protein 8

FUNCTION: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. {ECO:0000269|PubMed:12807892, ECO:0000269|PubMed:12899622, ECO:0000269|PubMed:12950167}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. {ECO:0000250}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

RISC_HUMAN
Q9HB40 - Retinoid-inducible serine carboxypeptidase

FUNCTION: May be involved in vascular wall and kidney homeostasis. {ECO:0000250}.

SUBCELLULAR LOCATION: Secreted {ECO:0000305}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

EMC7_HUMAN
Q9NPA0 - ER membrane protein complex subunit 7

SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:22119785}; Single-pass type I membrane protein {ECO:0000269|PubMed:22119785}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

TM254_HUMAN
Q8TBM7 - Transmembrane protein 254

SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

ERO1A_HUMAN
Q96HE7 - ERO1-like protein alpha

FUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870}.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Peripheral membrane protein {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Lumenal side {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

CNTP2_HUMAN
Q9UHC6 - Contactin-associated protein-like 2

FUNCTION: Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. {ECO:0000250|UniProtKB:Q9CPW0}.

SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9CPW0}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CPW0}. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:Q9CPW0}. Note=Expressed in the juxtaparadonal region. {ECO:0000250|UniProtKB:Q9CPW0}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

TXD15_HUMAN
Q96J42 - Thioredoxin domain-containing protein 15

SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

COX15_HUMAN
Q7KZN9 - Cytochrome c oxidase assembly protein COX15 homolog

FUNCTION: May be involved in the biosynthesis of heme A. {ECO:0000269|PubMed:12474143}.

SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:9878253}; Multi-pass membrane protein {ECO:0000269|PubMed:9878253}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

APLP2_HUMAN
Q06481 - Amyloid-like protein 2

FUNCTION: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). {ECO:0000250, ECO:0000269|PubMed:8307156}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

LRIG2_HUMAN
O94898 - Leucine-rich repeats and immunoglobulin-like domains protein 2

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15145052}; Single-pass type I membrane protein {ECO:0000269|PubMed:15145052}. Cytoplasm {ECO:0000269|PubMed:15145052}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

RS29_HUMAN
P62273 - 40S ribosomal protein S29

FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

GOLM1_HUMAN
Q8NBJ4 - Golgi membrane protein 1

FUNCTION: Unknown. Cellular response protein to viral infection.

SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}; Single-pass type II membrane protein {ECO:0000269|PubMed:10831838, ECO:0000269|PubMed:12191016}. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

OCLN_HUMAN
Q16625 - Occludin

FUNCTION: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19017651, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:9175707}; Multi- pass membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:10523508, ECO:0000269|PubMed:19017651, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:9175707}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

TR10B_HUMAN
O14763 - Tumor necrosis factor receptor superfamily member 10B

FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:10542098, ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:15322075}.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

ITA8_HUMAN
P53708 - Integrin alpha-8

FUNCTION: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269|PubMed:12415008, ECO:0000269|PubMed:15721307}.

SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24439109}; Single-pass type I membrane protein {ECO:0000269|PubMed:24439109}. Cell membrane {ECO:0000269|PubMed:24439109}.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

DSC3_HUMAN
Q14574 - Desmocollin-3

FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

CLEAVAGE EVENTS OBSERVED:

PLOT OF CLEAVAGE EVENTS:

GPC4_HUMAN
O75487 - Glypican-4

FUNCTION: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). {ECO:0000250}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.

FUNCTION: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.

FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.

SUBCELLULAR LOCATION: Isoform 1: Golgi apparatus lumen {ECO:0000250|UniProtKB:Q61112}.

SUBCELLULAR LOCATION: Isoform 5: Cytoplasm {ECO:0000269|PubMed:17442889}. Cell membrane {ECO:0000269|PubMed:17442889}. Cell projection, bleb. Note=Isoform 5 colocalizes with STX3 and STXBP1 isoform 2 at the plasma membrane and cell surface blebs. {ECO:0000269|PubMed:17442889}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
CAB45_HUMAN	DLGGFDEDAEPR	86	FLGK | DLGG

PLOT OF CLEAVAGE EVENTS:

CP51A_HUMAN
Q16850 - Lanosterol 14-alpha demethylase

FUNCTION: Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000269|PubMed:20149798, ECO:0000269|PubMed:8619637}.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
CP51A_HUMAN	AGGSVLGQAMEK	9	GLLQ | AGGS

PLOT OF CLEAVAGE EVENTS:

S39A6_HUMAN
Q13433 - Zinc transporter ZIP6

FUNCTION: May act as a zinc-influx transporter. {ECO:0000269|PubMed:12839489}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12839489}; Multi-pass membrane protein {ECO:0000269|PubMed:12839489}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
S39A6_HUMAN	FPQTTEK	29	KAAA | FPQT

PLOT OF CLEAVAGE EVENTS:

SHPS1_HUMAN
P78324 - Tyrosine-protein phosphatase non-receptor type substrate 1

FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. {ECO:0000250, ECO:0000269|PubMed:10469599, ECO:0000269|PubMed:11509594}.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
SHPS1_HUMAN	EEELQVIQPDK	31	GVAG | EEEL

PLOT OF CLEAVAGE EVENTS:

LAMA5_HUMAN
O15230 - Laminin subunit alpha-5

FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
LAMA5_HUMAN	AVAAEAQDTATR	2634	AHAK | AVAA

PLOT OF CLEAVAGE EVENTS:

IPRI_HUMAN
Q8IWB1 - Inositol 1,4,5-trisphosphate receptor-interacting protein

FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release. {ECO:0000269|PubMed:16990268}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16990268}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
IPRI_HUMAN	EALEQVAEEGR	67	AAEK | EALE

PLOT OF CLEAVAGE EVENTS:

TMED1_HUMAN
Q13445 - Transmembrane emp24 domain-containing protein 1

FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8621446}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
TMED1_HUMAN	AGPPPIQDGEFTFLLPAGR	24	EVGG | AGPP

PLOT OF CLEAVAGE EVENTS:

FKB14_HUMAN
Q9NWM8 - Peptidyl-prolyl cis-trans isomerase FKBP14

FUNCTION: PPIases accelerate the folding of proteins during protein synthesis.

SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:22265013}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
FKB14_HUMAN	ALIPEPEVK	20	SLIG | ALIP
FKB14_HUMAN	LIPEPEVK	21	LIGA | LIPE

PLOT OF CLEAVAGE EVENTS:

NPDC1_HUMAN
Q9NQX5 - Neural proliferation differentiation and control protein 1

FUNCTION: Suppresses oncogenic transformation in neural and non- neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity). {ECO:0000250}.

SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
NPDC1_HUMAN	GHPDVAACPGSLDCALK	35	GAAA | GHPD

PLOT OF CLEAVAGE EVENTS:

RAB5C_HUMAN
P51148 - Ras-related protein Rab-5C

FUNCTION: Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
RAB5C_HUMAN	GVDLQENNPASR	199	GRNR | GVDL

PLOT OF CLEAVAGE EVENTS:

SUSD5_HUMAN
O60279 - Sushi domain-containing protein 5

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
SUSD5_HUMAN	EAFHKPGLEK	299	WFPA | EAFH

PLOT OF CLEAVAGE EVENTS:

PLOD2_HUMAN
O00469 - Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

FUNCTION: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. {ECO:0000250|UniProtKB:P24802}.

SUBCELLULAR LOCATION: Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
PLOD2_HUMAN	ADSEKPSSIPTDK	26	PCLG | ADSE

PLOT OF CLEAVAGE EVENTS:

GPC3_HUMAN
P51654 - Glypican-3

FUNCTION: Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. {ECO:0000269|PubMed:17549790}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.

SUBCELLULAR LOCATION: Secreted glypican-3: Secreted, extracellular space {ECO:0000250}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
GPC3_HUMAN	HVEHEETLSSR	377	LKVA | HVEH

PLOT OF CLEAVAGE EVENTS:

SELM_HUMAN
Q8WWX9 - Selenoprotein M {ECO:0000303|PubMed:27645994}

FUNCTION: May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. {ECO:0000250}.

SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11839807}. Endoplasmic reticulum {ECO:0000305|PubMed:11839807}. Golgi apparatus {ECO:0000305|PubMed:11839807}. Note=Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
SELM_HUMAN	ATAYRPDWNR	24	PATA | ATAY

PLOT OF CLEAVAGE EVENTS:

ADA10_HUMAN
O14672 - Disintegrin and metalloproteinase domain-containing protein 10

FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). {ECO:0000250|UniProtKB:O35598, ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905, ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:26686862}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:12475894}; Single-pass type I membrane protein {ECO:0000305}. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi. {ECO:0000269|PubMed:12475894}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
ADA10_HUMAN	GQYGNPLNK	19	AGMG | GQYG

PLOT OF CLEAVAGE EVENTS:

MATR3_HUMAN
P43243 - Matrin-3

FUNCTION: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. {ECO:0000269|PubMed:11525732}.

SUBCELLULAR LOCATION: Nucleus matrix.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
MATR3_HUMAN	SFQQSSLSR	4	#NAME? | SFQQ

PLOT OF CLEAVAGE EVENTS:

KDEL2_HUMAN
Q7Z4H8 - KDEL motif-containing protein 2

SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
KDEL2_HUMAN	GAPEVLVSAPR	21	LVAA | GAPE

PLOT OF CLEAVAGE EVENTS:

LYOX_HUMAN
P28300 - Protein-lysine 6-oxidase

FUNCTION: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). {ECO:0000250|UniProtKB:P28301, ECO:0000269|PubMed:26838787}.

SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P28301}. Secreted, extracellular space.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
LYOX_HUMAN	SLGSQYQPQR	59	FSLL | SLGS

PLOT OF CLEAVAGE EVENTS:

GPC6_HUMAN
Q9Y625 - Glypican-6

FUNCTION: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. {ECO:0000250, ECO:0000269|PubMed:21871017}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.

SUBCELLULAR LOCATION: Secreted glypican-6: Secreted, extracellular space {ECO:0000250}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
GPC6_HUMAN	SAPENFNTR	355	RSAR | SAPE

PLOT OF CLEAVAGE EVENTS:

SELT_HUMAN
P62341 - Selenoprotein T {ECO:0000303|PubMed:27645994}

FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP- induced insulin secretion (By similarity). {ECO:0000250|UniProtKB:P62342, ECO:0000250|UniProtKB:Q1H5H1, ECO:0000269|PubMed:26866473}.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein {ECO:0000255}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
SELT_HUMAN	SANLGGVPSK	20	RSEA | SANL

PLOT OF CLEAVAGE EVENTS:

COX5B_HUMAN
P10606 - Cytochrome c oxidase subunit 5B, mitochondrial

FUNCTION: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

SUBCELLULAR LOCATION: Mitochondrion inner membrane.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
COX5B_HUMAN	ASGGGVPTDEEQATGLER	32	MRSM | ASGG

PLOT OF CLEAVAGE EVENTS:

SCO1_HUMAN
O75880 - Protein SCO1 homolog, mitochondrial

FUNCTION: Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX. {ECO:0000269|PubMed:15659396, ECO:0000269|PubMed:16735468, ECO:0000269|PubMed:17189203}.

SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9878253}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
SCO1_HUMAN	STARPPPPWSQK	68	TRPL | STAR

PLOT OF CLEAVAGE EVENTS:

CELR2_HUMAN
Q9HCU4 - Cadherin EGF LAG seven-pass G-type receptor 2

FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
CELR2_HUMAN	AIDPDEGEAGR	205	ASLR | AIDP

PLOT OF CLEAVAGE EVENTS:

CO2A1_HUMAN
P02458 - Collagen alpha-1(II) chain {ECO:0000305}

FUNCTION: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
CO2A1_HUMAN	SLNNQIESIR	1261	ATLK | SLNN

PLOT OF CLEAVAGE EVENTS:

EPHA3_HUMAN
P29320 - Ephrin type-A receptor 3

FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}.

SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000269|PubMed:11870224}; Single-pass type I membrane protein {ECO:0000255}.

SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000269|PubMed:21135139}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
EPHA3_HUMAN	ELIPQPSNEVNLLDSK	21	DSFG | ELIP

PLOT OF CLEAVAGE EVENTS:

TECT3_HUMAN
Q6NUS6 - Tectonic-3

FUNCTION: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. {ECO:0000250, ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:22883145}.

SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
TECT3_HUMAN	STAASLTSPR	370	AFQQ | STAA

PLOT OF CLEAVAGE EVENTS:

S39AE_HUMAN
Q15043 - Zinc transporter ZIP14

FUNCTION: Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron. {ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:27231142}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27231142}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:27231142}. Cell projection, lamellipodium {ECO:0000269|PubMed:12659941, ECO:0000269|PubMed:15642354}. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae. {ECO:0000269|PubMed:12659941, ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:27231142}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
S39AE_HUMAN	SSLGAPAISAASFLQDLIHR	31	EAHA | SSLG

PLOT OF CLEAVAGE EVENTS:

RTN4R_HUMAN
Q9BZR6 - Reticulon-4 receptor

FUNCTION: Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). {ECO:0000250|UniProtKB:Q99PI8, ECO:0000269|PubMed:12037567, ECO:0000269|PubMed:12426574, ECO:0000269|PubMed:12839991, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:16712417, ECO:0000269|PubMed:18411262}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12426574, ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:12839991, ECO:0000269|PubMed:16712417, ECO:0000269|PubMed:18411262}; Lipid- anchor, GPI-anchor {ECO:0000269|PubMed:12694398}. Membrane raft {ECO:0000269|PubMed:12694398}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99PI8}. Cell projection, axon {ECO:0000250|UniProtKB:Q99PI8}. Perikaryon {ECO:0000250|UniProtKB:Q99M75}. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. {ECO:0000250|UniProtKB:Q99PI8}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
RTN4R_HUMAN	SVLEPGRPASAGNALK	345	ADKA | SVLE

PLOT OF CLEAVAGE EVENTS:

JTB_HUMAN
O76095 - Protein JTB

FUNCTION: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250, ECO:0000269|PubMed:21225229}.

SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
JTB_HUMAN	EAPVQEEK	31	LCQA | EAPV

PLOT OF CLEAVAGE EVENTS:

QSOX2_HUMAN
Q6ZRP7 - Sulfhydryl oxidase 2

FUNCTION: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. {ECO:0000269|PubMed:14633699}.

SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:14633699}; Single-pass membrane protein {ECO:0000269|PubMed:14633699}. Secreted {ECO:0000269|PubMed:14633699}. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
QSOX2_HUMAN	EFTTGENFK	151	AFTK | EFTT

PLOT OF CLEAVAGE EVENTS:

TMX3_HUMAN
Q96JJ7 - Protein disulfide-isomerase TMX3

FUNCTION: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. {ECO:0000269|PubMed:15623505}.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15623505}; Single-pass membrane protein {ECO:0000269|PubMed:15623505}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
TMX3_HUMAN	SSIASEFGVR	88	ATSY | SSIA

PLOT OF CLEAVAGE EVENTS:

SDF2_HUMAN
Q99470 - Stromal cell-derived factor 2

SUBCELLULAR LOCATION: Secreted {ECO:0000305}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
SDF2_HUMAN	SSLGVVTCGSVVK	19	AVGA | SSLG

PLOT OF CLEAVAGE EVENTS:

NEMP2_HUMAN
A6NFY4 - Nuclear envelope integral membrane protein 2

SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q6ZQE4}; Multi-pass membrane protein {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
NEMP2_HUMAN	EAAAAALSVR	25	PVRG | EAAA

PLOT OF CLEAVAGE EVENTS:

CDON_HUMAN
Q4KMG0 - Cell adhesion molecule-related/down-regulated by oncogenes

FUNCTION: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). {ECO:0000250}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
CDON_HUMAN	NTQASSPPVGIPK	683	ASSK | NTQA

PLOT OF CLEAVAGE EVENTS:

PO210_HUMAN
Q8TEM1 - Nuclear pore membrane glycoprotein 210

FUNCTION: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}.

SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:2195063}. Nucleus membrane {ECO:0000269|PubMed:2195063}; Single-pass type I membrane protein {ECO:0000269|PubMed:2195063}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:2195063}; Single-pass type I membrane protein {ECO:0000269|PubMed:2195063}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
PO210_HUMAN	AVDPTSGQLYGLAR	1259	VVVK | AVDP

PLOT OF CLEAVAGE EVENTS:

P3H1_HUMAN
Q32P28 - Prolyl 3-hydroxylase 1 {ECO:0000312|HGNC:HGNC:19316}

FUNCTION: Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. {ECO:0000269|PubMed:10951563}.

SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum.

SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG). {ECO:0000269|PubMed:19088120}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
P3H1_HUMAN	SQEIGNLMK	418	AVRI | SQEI

PLOT OF CLEAVAGE EVENTS:

FAM3C_HUMAN
Q92520 - Protein FAM3C

FUNCTION: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasmic vesicle {ECO:0000269|PubMed:16959614}. Note=Cytoplasmic in some cancer cells.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
FAM3C_HUMAN	SALDTAAR	42	LFAR | SALD

PLOT OF CLEAVAGE EVENTS:

SEC63_HUMAN
Q9UGP8 - Translocation protein SEC63 homolog

FUNCTION: Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
SEC63_HUMAN	AALTDEESR	150	AKAY | AALT

PLOT OF CLEAVAGE EVENTS:

PLD3_HUMAN
Q8IV08 - Phospholipase D3

FUNCTION: May be involved in APP processing. {ECO:0000305|PubMed:24336208}.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15794758}; Single-pass type II membrane protein {ECO:0000269|PubMed:15794758}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
PLD3_HUMAN	SAPPPLCPSGR	294	AYLA | SAPP

PLOT OF CLEAVAGE EVENTS:

NR3L1_HUMAN
Q68D85 - Natural cytotoxicity triggering receptor 3 ligand 1

FUNCTION: Triggers NCR3-dependent natural killer cell activation. {ECO:0000269|PubMed:19528259}.

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19528259}; Single-pass type I membrane protein {ECO:0000269|PubMed:19528259}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
NR3L1_HUMAN	SLHTPLR	234	VRHA | SLHT

PLOT OF CLEAVAGE EVENTS:

AMD_HUMAN
P19021 - Peptidyl-glycine alpha-amidating monooxygenase

FUNCTION: Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

SUBCELLULAR LOCATION: Isoform 1: Membrane; Single-pass type I membrane protein.

SUBCELLULAR LOCATION: Isoform 2: Membrane; Single-pass type I membrane protein.

SUBCELLULAR LOCATION: Isoform 3: Secreted. Note=Secreted from secretory granules.

SUBCELLULAR LOCATION: Isoform 4: Secreted. Note=Secreted from secretory granules.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
AMD_HUMAN	GIEVQEIK	821	VKKA | GIEV

PLOT OF CLEAVAGE EVENTS:

NID1_HUMAN
P14543 - Nidogen-1

FUNCTION: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions.

SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
NID1_HUMAN	SVPSVLSPR	327	ADTY | SVPS

PLOT OF CLEAVAGE EVENTS:

LRRD1_HUMAN
A4D1F6 - Leucine-rich repeat and death domain-containing protein 1

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
LRRD1_HUMAN	ALNLFTR	850	DKIT | ALNL

PLOT OF CLEAVAGE EVENTS:

S29A1_HUMAN
Q99808 - Equilibrative nucleoside transporter 1

FUNCTION: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
S29A1_HUMAN	AAPAAPLPER	64	AQAS | AAPA

PLOT OF CLEAVAGE EVENTS:

CSTN1_HUMAN
O94985 - Calsyntenin-1

FUNCTION: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250, ECO:0000269|PubMed:12972431}.

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17332754}; Single-pass type I membrane protein {ECO:0000269|PubMed:17332754}. Golgi apparatus membrane {ECO:0000269|PubMed:17332754}. Cell projection {ECO:0000269|PubMed:17332754}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17332754}. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250}.

CLEAVAGE EVENTS OBSERVED:

Protein	Peptide	Cleavage Position (P1')	Cleavage Site P4-P1 | P1'-P4'
CSTN1_HUMAN	ATVELETSHIGK	301	ASVQ | ATVE

PLOT OF CLEAVAGE EVENTS: